Scombroid (Histamine) Poisoning

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Allergic reaction to some fish and fermented foods

Scombroid poisoning occurs if temperature control of raw scombroid fish (mackerel, tuna and bonito – see ‘Reservoirs’ below) is compromised, allowing bacteria which produce toxins to grow. Similar toxins can also be produced in other foods – notably cheese and other fermented foodstuffs. While histamine poisoning is well known and is by far the most important form, a range of different related toxins called biogenic amines, can cause disease.

Biogenic Amines Clinical Notes Reservoirs / Sources
Many types of bacteria are capable of producing the biogenic amines regarded as the cause of histamine poisoning. Also, the enzymes responsible (decarboxylases), once produced, may still be active even if the bacteria that produced them are subsequently controlled. Control of biogenic amine production is best summarised by food type.


Histamine food poisoning is most often associated with a particular group of fish that have high free levels of the amino acid histidine (i.e. not contained in proteins) in their flesh. Fresh scombroid fishes do not contain free histamine, and amines are only produced during if temperature control fails or spoilage. For example storage of mackerel for 18 days at 0°C will result in little histamine formation, but high levels will be found after a few days’ storage at 10°C. Scombroid fish can have a 14 day safe shelf life at 0°C if chilled quickly (meaning reducing the internal temperature to 10°C or less in 6 hours), but this reduces to only 7 days at 4.4°C (these times include time on the boat). The fish should not be exposed to temperatures >4.4°C for more than 4 hours after the initial chilling. Vacuum packaging is not an effective means of retarding the production of amines. Salting may result in the selection of salt-tolerant bacteria that may also produce amines. Preservatives, or other interventions that inhibit the growth of bacteria, will also inhibit the production of amines. Fish will store indefinitely if frozen.


Biogenic amines are produced during ripening as the casein is slowly degraded by enzymatic activity to release free amino acids which may act as substrates for decarboxylation. The use of pasteurised milk, hygienic practice and the use of starter cultures with low decarboxylase activity assist in the prevention of amine formation. Ripening at warm temperatures, as is practiced in Swiss style cheese production, has the potential to allow the formation of biogenic amines. The addition of proteolytic enzymes to decrease ripening times releases free amino acids from proteins and in some circumstances this results in increased amine concentrations in some circumstances (i.e. where raw milk is used as an ingredient). Long ripening periods (>6 months) also contribute to the potential for amine production. pH during ripening is also important with lower pH resulting in less amine formation.


Amines can accumulate during the production of fermented meat products. Foods such as salamis should be made from good quality raw ingredients. Frozen ingredients of suitable quality can be thawed at 5°C for 3 days when a starter culture is used. Short fermentations and the use of appropriate starter cultures used under optimum conditions assist in reducing amine formation (possibly by the rapid decrease in pH that results). In fresh meats amine production is correlated with spoilage, so minimising the possibility of intoxication occurring as the consumer is alerted to the poor quality of the food. However, new packaging technologies might erode this safeguard. Levels of tyramine toxic to those on monoamine oxidase inhibitor (MAOI) drugs have been demonstrated in beef stored at +2 and –2°C for 100 days, and in pork stored at -1.5°C for up to 13 weeks in preservative packaging.

Fermented Vegetables

Hygienic practice and the use of starter cultures with low decarboxylase activity assist in the prevention of amine formation.

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Ranges from several minutes to several hours. Mean incubation period around 1 hour.


Normally lasts for a few hours but can last for days.


Histamine: may include rash, localised skin inflammation, nausea, vomiting, diarrhoea, abdominal cramps, low blood pressure, headache, tingling, flushing and severe respiratory distress. The most consistent sign is a flushing of the face and neck causing heat and discomfort, which can appear similar to sunburn. Tyramine: this acts indirectly to increase blood pressure by narrowing peripheral blood vessels and increasing the output from the heart. Other symptoms include dilation of the pupils, swelling of the eyes and tear production, salivation, increased respiration and blood sugar concentration.


The actual nature of the toxin is the subject of much debate, at least in fish. The biological effects of histamine are reported to be increased in the presence of other spoilage products, as fish containing a level of histamine seem to be more toxic than the same amount of histamine administered orally by itself. Another theory suggests that an unknown toxin from spoiled fish actually mediates the release of histamine from the body’s cells. Whatever the actual toxin(s) involved, biogenic amines in food are at least indicators of the presence of these toxin(s).

At Risk Groups

All consumers are at risk, although there may be sub-groups of different susceptibilities. People on MAOI therapy who consume tyramine are susceptible to hypertensive crisis. The enzymes that these drugs inhibit are those that remove these toxins in healthy individuals.

Long Term Effects

Rarely, cardiac and respiratory complications occur.


The situation regarding a toxic dose is unclear (not least because the chemical(s) responsible is not known). Approximately 100 mg/100g histamine is considered to be toxic, but a number of incidents have involved foods containing less than 5 mg/100g histamine. A limit commonly used is 30 mg/100g. Another scheme states that <5mg/100g is safe to eat, 5-20mg/100g is possibly toxic, 20-100 mg/100g is probably toxic and >100 mg/100g is toxic and unsafe for human consumption. For tyramine a toxic dose of 10-80 mg has been suggested.


Administration of antihistamines for histamine poisoning.


Scombroid fish are the most likely to be involved with histamine poisoning. These include mackerel, tuna, bonito, and butterfly kingfish. Other fish species also implicated include sardines, pilchards, anchovies, herring and marlin. Fermented fish products may contain appreciable levels of histamine but there is no association between consuming this sort of food and disease.


Fermented meats may contain sufficient toxin to pose a theoretical risk to human health


Cheeses involved in outbreaks include Gouda, Swiss, Cheddar, Gruyere and Cheshire.

Alcoholic Drinks

A case has been described where a person on MAOI therapy became symptomatic after the consumption of 250 ml beer. Yeasts do not form amines and so the amines in beer are derived from the raw materials or are due to microbial contamination during fermentation. The presence of amines in wine (mostly red) has also been reported.

Fermented Vegetables

Commercial sauerkraut (fermented cabbage) can contain appreciable levels of amines, although the level is usually below what can be regarded as toxic.

Other Fruits and Vegetables

Some fruits can contain appreciable levels of amines, for example raspberry juice has a relatively high tyramine concentration. Amines are also present in a variety of vegetables. Levels will generally be below that regarded as being toxic.

Soy / Asian Food Products

High levels of amines have been measured in some soy sauces (inyu), fermented black soybeans (toushi) and fermented soybean curd (sofu).

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